Yesterday, Tuesday, December 2nd, Surescripts has encountered a HTTP communication failure with pharmacy mailboxing services. This may have caused some prescriptions to queue, fax, or fail.
Your providers may have seen this message:
Error sending message to mailbox service - Http Communication Problem: Mailbox message was not accepted by mailbox service
This was resolved the same day, 12/2/25 at 4:55 PM eastern.
Recommended Actions: Non-Controlled substances were attempted to be faxed to the pharmacy. Any failed message should be resent.
Any questions, please reach out to Ensora ERX Support. Thank you.